Bagnall, N. and Gough, J. and Cadogan, L. and Burns, B. and Kongsuwan, K. (2009) Expression of intracellular calcium signalling genes in cattle skin during tick infestation. Parasite Immunology, 31 (4). pp. 177-187.
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Article Link(s): http://dx.doi.org/10.1111/j.1365-3024.2008.01092.x
Publisher URL: http://www3.interscience.wiley.com/cgi-bin/home
It is widely acknowledged that changes in intracellular calcium ion (Ca2+) concentration provide dynamic signals that control a plethora of cellular processes, including triggering and mediating host defence mechanisms. In this study, quantitative real-time PCR was used to analyse gene expression of 14 Ca2+ signalling proteins in skin obtained from high tick-resistant (HR) and low tick-resistant (LR) cattle following artificial challenge with cattle tick (Rhipicephalus (Boophilus) microplus). Up-regulation of numerous genes was observed in both HR and LR skin following tick challenge, however substantially higher transcription activation was found in HR tissue. The elevated expression in HR skin of specific Ca2+ signalling genes such as AHNAK, CASQ, IL2, NFAT2CIP and PLCG1 may be related to host resistance. Our data suggest that Ca2+ and its associated proteins might play an important role in host response to ticks and that further investigation is warranted.
|Additional Information:||© Blackwell Publishing Ltd.|
|Keywords:||Calcium signalling; gene expression; Rhipicephalus (Boophilus) microplus; tick resistance; T-cell activation; salivary protein; host resistance; calreticulin; receptor; immunoglobulin.|
|Subjects:||Science > Biology > Molecular Biology|
Agriculture > Animal culture > Cattle
Animal culture > Cattle
Agriculture > Veterinary medicine > Veterinary parasitology
Veterinary medicine > Veterinary parasitology
|Deposited On:||16 Apr 2009 03:40|
|Last Modified:||17 Jun 2011 00:40|
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